A checkpoint regulator involved in attachment surveillance and inhibitory complexes controlling anaphase-promoting complex–Cdc20.
Checkpoint signalling restrains activation of the anaphase-promoting complex until suitable attachment conditions are reached. Inhibitory-complex assembly and the physical correction of attachments are related but distinct tasks, so one checkpoint readout need not establish normal chromosome alignment. [ref]
Molecular Biology of the Cell, 4th edition by Bruce Alberts and others. Chapter 17, The Spindle Assembly Checkpoint
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