 Crystal Structure of Prothrombin Reveals Conformational Flexibility and Mechanism of Activation by Nicola Pozzi and others

Journal of Biological Chemistry 288(31), pp.22734–22744, issue 2 August 2013; DOI 10.1074/jbc.M113.466946. Abstract and Fig.1: engineered Gla-domainless S525A precursor, cleavage sites and activation. Structural construct and interpretation must be stated; cleavage order is condition-dependent.