 E. E. Fesenko

E. E. Fesenko is the first author of a 1985 experiment showing that cyclic guanosine monophosphate can directly increase electrical conductance in membrane patches from rod cells. The original publisher gives the byline Evgeniy E. Fesenko; the initial-only article title is retained.^[ref]

The investigators excised inside-out membrane patches and applied cyclic guanosine monophosphate to the exposed inner face. Conductance increased reversibly even without nucleoside triphosphates, arguing against a requirement for an intervening phosphorylation reaction in that preparation. Related tested nucleotides did not reproduce the effect.^[ref]

Excising a patch simplified the experiment: an electrical response could be tested without the entire photoreceptor remaining intact. It supported a membrane-local action of the signal, while leaving the complete light-response sequence in a living rod cell as a further question.