 High frequency of BRAF mutations in nevi by Pamela M. Pollock and others

Pamela M. Pollock and colleagues, Nature Genetics 33(1), 19–20, January 2003; first online 25 November 2002. DOI 10.1038/ng1054. Abstract: mutation analysis of microdissected samples found the substitution labeled V599E in the original paper in 63 of 77 nevi; the authors distinguish an initiating pathway alteration from sufficient evidence for melanoma tumorigenesis.