HSFA2 is a heat-shock transcriptional regulator involved in sustained stress responses in Arabidopsis thaliana. Its role in somatic stress memory can outlast its direct occupancy of target regions.
Experiments found transient association of HSFA2 with memory-related loci together with longer-lasting histone methylation and altered responses to a subsequent heat exposure. The distinction between the initial response and later memory is crucial: HSFA2 dependence of the latter does not imply dependence of every immediate heat response.[ref]
A hit-and-run heat shock factor governs sustained histone methylation and transcriptional stress memory by Jörn Lämke and others. Abstract, transient association and persistent H3K4 methylation
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