Kandice R. Levental investigated how crosslinking of the extracellular matrix affects integrin signaling and tumour behaviour. The experimental study connected changes in matrix mechanics with cell signaling and invasion, making the surrounding material's physical properties part of the biological explanation.[ref]
Matrix crosslinking forces tumor progression by enhancing integrin signaling by Kandice R. Levental and others. 2009, matrix crosslinking, integrin clustering and invasion experiments
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