KRAS4B is a Ras isoform with a prenylated membrane-targeting region and a polybasic region. Contacts between its folded domain and the membrane can alter access to effector-binding surfaces.[ref]
Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site by Mohammad T. Mazhab-Jafari and others. pp. 6625–6630, nanodisc NMR and membrane-facing orientations
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