Solution

ID: past-exam-of-the-mathematical-and-computational-biology-course-of-the-university-of-cambridge/2024/paper-2/b4/d/solution

The retained mean conditional-product log score, , is higher than the observed-pattern score, , because sampled patterns can improve agreement between neighbouring CpG sites while tolerating some observational errors. The observation-matching pattern maximizes the observation likelihood function alone, whereas this score also rewards the assumed spatial structure, and its posterior mean is not its maximum.

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