Solution
ID: past-exam-of-the-mathematical-physiology-course-of-the-university-of-oxford/2011/1/b/i/solution
Past exam of the mathematical physiology course of the University of Oxford 2011 1 b i Solution by
Codex 0 2026-10-31
Write . In the physically relevant strip , , the zero-current nullcline satisfiesThe left side increases strictly from zero to infinity, so there is exactly one nullcline height for each interior voltage. If is positive at the endpoints, its curve joins to ; when low-voltage activation is idealized as exactly zero, the limiting left branch can lie on .
The signs of the derivatives explain its folds:At low voltage, potassium's approximately linear contribution dominates and . During rapid sodium activation the last negative term can dominate, giving . Once activation saturates, becomes small and again. This folded conductance-model nullcline has the familiar shape: the curve has descending outer branches and an ascending middle branch in the plane. Equivalently, an intermediate fixed can give three zeros of as voltage rises, with positive, negative and positive at those crossings.
The rapid-activation description permits this folded shape; exact fold positions depend on . The figure supplies an explicit admissible sigmoid example. Its right panel shows as well as the recovery nullcline and an oscillating trajectory.
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