 Solution

Let $p_1,p_3$ label the incoming and outgoing fermion, and $p_2,p_4$ the incoming and outgoing antifermion. The bottom row of the figure gives the two tree-level Feynman diagrams:

Thus the Mandelstam variables in the two denominators areThe two scattering amplitude terms have a relative fermionic sign of minus when written with spinor products $({\bar{u}}_3{u}_1)({\bar{v}}_2{v}_4)$ and $({\bar{v}}_2{u}_1)({\bar{u}}_3{v}_4)$. The overall phase depends on the chosen ordering of the external states. No $u$ channel joins an incoming fermion to an outgoing antifermion through a species-preserving Yukawa interaction.