 Solution

ID: past-exam-of-the-systems-biology-course-of-the-university-of-cambridge/2024/paper-4/section-i/1-14/solution

Two useful changes would be:

Show patient estimates together with matched, relevant cell-type controls and an independent measurement of modification at prespecified or held-out loci. Display uncertainty and all evaluated loci, or state a selection rule independent of the reported contrast. This separates genuine agreement from selection of high xPore values and from unrelated cell-background effects.
Add performance across measured RNA-input levels for the same biological materials, with biological and technical replication, read coverage and failure rates reported. This tests the low-input part of the claim directly rather than inferring it from the heatmap.

A single additional knockout row would not address both independent accuracy and input dependence.

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