R. Nahum is the first author of a 1995 study of hormone regulation in human theca cells. The investigators maintained the cells in serum-free culture and measured androstenedione after four days, testing insulin and related growth signals with and without luteinizing hormone.[ref]
Metabolic regulation of androgen production by human thecal cells in vitro by R. Nahum and others. Abstract: culture design, treatment comparisons and androstenedione assay; Human Reproduction 10, 75–81, 1995
Hormone output increased under the tested conditions without a corresponding stimulation of cell growth. That distinction matters when interpreting a culture assay: more product can reflect changed activity of the cells already present, rather than simply a larger population. The experiment identified regulation of androgen production in this cultured system; it did not by itself establish how the same intervention would behave in a whole person.[ref]
Metabolic regulation of androgen production by human thecal cells in vitro by R. Nahum and others. Abstract: increased steroid production without stimulated thecal-cell growth
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