Romain Melot investigated total synthesis strategies based on carbon–hydrogen bond activation. One sequence combines extensive bromination with selective removal of bromine, illustrating how temporary substitution can guide the preparation of a chosen aromatic substitution pattern.[ref]
Total Synthesis of (Nor)illudalane Sesquiterpenes Based on a C(sp3)-H Activation Strategy by Romain Melot and others. 2019, Scheme6: perbromination and selective HI debromination of 2,5-xylenol
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