 Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1 by Jeong Ho Chang and others

Nature Structural and Molecular Biology18(3),270–276(2011), DOI10.1038/nsmb.1984. Primary first-author byline Jeong Ho Chang verified. Abstract/Results: Xrn1 direction,2.9Å structures of a K.lactis E178Q construct and mutagenesis showing roles of remote domains in stabilizing the catalytic architecture. Construct not conflated with intact wild-type enzyme.

Additional locators: Introduction and Figure5, end-specific processive RNA degradation.