Thomas C. Coombs coauthored 1,3-Allylic Strain as a Strategic Diversification Element for Constructing Libraries of Substituted 2-Arylpiperidines by Thomas C. Coombs and others.
Allylic strain arises from unfavorable spatial contacts among substituents associated with an alkene and a neighboring saturated center. The publication uses 1,3-allylic strain as a conformational design element in constructing substituted piperidines, connecting a local steric interaction with control of a synthetic scaffold.
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