William S. Johnson developed a stereoselective orthoester variant of the Claisen rearrangement. The 1970 report connects the method with formation of trans-trisubstituted carbon–carbon double bonds and the synthesis of squalene.[ref]
Simple stereoselective version of the Claisen rearrangement by William S. Johnson and colleagues. 1970, full title and original orthoester Claisen method
New to topics? Read the docs here!