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1Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae by Miki Tsukada and Yoshinori Ohsumiisolation-and-characterization-of-autophagy-defective-mutants-of-saccharomyces-cerevisiae-by-miki-tsukada-and-yoshinori-ohsumi2026-10-202026-10-20
1Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing by Dirk Remus and othersconcerted-loading-of-mcm2-7-double-hexamers-around-dna-during-dna-replication-origin-licensing-by-dirk-remus-and-others2026-10-202026-10-20
1Driving the cell cycle with a minimal CDK control network by Damien Coudreuse and Paul Nursedriving-the-cell-cycle-with-a-minimal-cdk-control-network-by-damien-coudreuse-and-paul-nurse2026-10-202026-10-20
1Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion by Akira Orimo and othersstromal-fibroblasts-present-in-invasive-human-breast-carcinomas-promote-tumor-growth-and-angiogenesis-through-elevated-sdf-1-cxcl12-secretion-by-akira-orimo-and-others2026-10-202026-10-20
1A paracrine loop between tumor cells and macrophages is required for tumor cell migration in mammary tumors by Jeffrey Wyckoff and othersa-paracrine-loop-between-tumor-cells-and-macrophages-is-required-for-tumor-cell-migration-in-mammary-tumors-by-jeffrey-wyckoff-and-others2026-10-202026-10-20
1Tumour exosome integrins determine organotropic metastasis by Ayuko Hoshino and otherstumour-exosome-integrins-determine-organotropic-metastasis-by-ayuko-hoshino-and-others2026-10-202026-10-20
1Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion by Cristovão M. Sousa and otherspancreatic-stellate-cells-support-tumour-metabolism-through-autophagic-alanine-secretion-by-cristovao-m-sousa-and-others2026-10-202026-10-20
1Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival by Berna C. Özdemir and othersdepletion-of-carcinoma-associated-fibroblasts-and-fibrosis-induces-immunosuppression-and-accelerates-pancreas-cancer-with-reduced-survival-by-berna-c-ozdemir-and-others2026-10-202026-10-20
1Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1 by Frank Uhlmann and otherssister-chromatid-separation-at-anaphase-onset-is-promoted-by-cleavage-of-the-cohesin-subunit-scc1-by-frank-uhlmann-and-others2026-10-202026-10-20
1An ECT2-centralspindlin complex regulates the localization and function of RhoA by Özlem Yüce and othersan-ect2-centralspindlin-complex-regulates-the-localization-and-function-of-rhoa-by-ozlem-yuce-and-others2026-10-202026-10-20
1Aurora B-mediated abscission checkpoint protects against tetraploidization by Patrick Steigemann and othersaurora-b-mediated-abscission-checkpoint-protects-against-tetraploidization-by-patrick-steigemann-and-others2026-10-202026-10-20
1Regulated eukaryotic DNA replication origin firing with purified proteins by Joseph T. P. Yeeles and othersregulated-eukaryotic-dna-replication-origin-firing-with-purified-proteins-by-joseph-t-p-yeeles-and-others2026-10-202026-10-20
1Independent and stochastic action of DNA polymerases in the replisome by James E. Graham and othersindependent-and-stochastic-action-of-dna-polymerases-in-the-replisome-by-james-e-graham-and-others2026-10-202026-10-20
1Oncogenic signaling pathways in The Cancer Genome Atlas by Francisco Sanchez-Vega and othersoncogenic-signaling-pathways-in-the-cancer-genome-atlas-by-francisco-sanchez-vega-and-others2026-10-202026-10-20
1Mutational heterogeneity in cancer and the search for new cancer-associated genes by Michael S. Lawrence and othersmutational-heterogeneity-in-cancer-and-the-search-for-new-cancer-associated-genes-by-michael-s-lawrence-and-others2026-10-202026-10-20
1Universal patterns of selection in cancer and somatic tissues by Iñigo Martincorena and othersuniversal-patterns-of-selection-in-cancer-and-somatic-tissues-by-inigo-martincorena-and-others2026-10-202026-10-20
1Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR by Anirudh Prahallad and othersunresponsiveness-of-colon-cancer-to-braf-v600e-inhibition-through-feedback-activation-of-egfr-by-anirudh-prahallad-and-others2026-10-202026-10-20
1Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis by Jing Yang and otherstwist-a-master-regulator-of-morphogenesis-plays-an-essential-role-in-tumor-metastasis-by-jing-yang-and-others2026-10-202026-10-20
1Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis by Jeff H. Tsai and othersspatiotemporal-regulation-of-epithelial-mesenchymal-transition-is-essential-for-squamous-cell-carcinoma-metastasis-by-jeff-h-tsai-and-others2026-10-202026-10-20
1Identification of the tumour transition states occurring during EMT by Ievgenia Pastushenko and othersidentification-of-the-tumour-transition-states-occurring-during-emt-by-ievgenia-pastushenko-and-others2026-10-202026-10-20

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Pinned article: Introduction to the OurBigBook Project

Welcome to the OurBigBook Project! Our goal is to create the perfect publishing platform for STEM subjects, and get university-level students to write the best free STEM tutorials ever.
Everyone is welcome to create an account and play with the site: ourbigbook.com/go/register. We belive that students themselves can write amazing tutorials, but teachers are welcome too. You can write about anything you want, it doesn't have to be STEM or even educational. Silly test content is very welcome and you won't be penalized in any way. Just keep it legal!
Video 1.
Intro to OurBigBook
. Source.
We have two killer features:
  1. topics: topics group articles by different users with the same title, e.g. here is the topic for the "Fundamental Theorem of Calculus" ourbigbook.com/go/topic/fundamental-theorem-of-calculus
    Articles of different users are sorted by upvote within each article page. This feature is a bit like:
    • a Wikipedia where each user can have their own version of each article
    • a Q&A website like Stack Overflow, where multiple people can give their views on a given topic, and the best ones are sorted by upvote. Except you don't need to wait for someone to ask first, and any topic goes, no matter how narrow or broad
    This feature makes it possible for readers to find better explanations of any topic created by other writers. And it allows writers to create an explanation in a place that readers might actually find it.
    Figure 1.
    Screenshot of the "Derivative" topic page
    . View it live at: ourbigbook.com/go/topic/derivative
    Video 2.
    OurBigBook Web topics demo
    . Source.
  2. local editing: you can store all your personal knowledge base content locally in a plaintext markup format that can be edited locally and published either:
    This way you can be sure that even if OurBigBook.com were to go down one day (which we have no plans to do as it is quite cheap to host!), your content will still be perfectly readable as a static site.
    Figure 2.
    You can publish local OurBigBook lightweight markup files to either OurBigBook.com or as a static website
    .
    Figure 3.
    Visual Studio Code extension installation
    .
    Figure 4.
    Visual Studio Code extension tree navigation
    .
    Figure 5.
    Web editor
    . You can also edit articles on the Web editor without installing anything locally.
    Video 3.
    Edit locally and publish demo
    . Source. This shows editing OurBigBook Markup and publishing it using the Visual Studio Code extension.
    Video 4.
    OurBigBook Visual Studio Code extension editing and navigation demo
    . Source.
  3. https://raw.githubusercontent.com/ourbigbook/ourbigbook-media/master/feature/x/hilbert-space-arrow.png
  4. Infinitely deep tables of contents:
    Figure 6.
    Dynamic article tree with infinitely deep table of contents
    .
    Descendant pages can also show up as toplevel e.g.: ourbigbook.com/cirosantilli/chordate-subclade
All our software is open source and hosted at: github.com/ourbigbook/ourbigbook
Further documentation can be found at: docs.ourbigbook.com
Feel free to reach our to us for any help or suggestions: docs.ourbigbook.com/#contact
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