The most important ones are:
- theory of everything. We are certain that our base equations are wrong, but we don't know how to fix them :-)
- full explanation of high-temperature superconductivity. Superconductivity already has a gazillion applications, and doing it in higher temperatures would add a gazillion more, and maybe this theoretical explanation would help us find new high temperature superconducting materials more effectively
- fractional quantum Hall effect 5/2
Other super important ones:
- neutrino mass measurement and explanation
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