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Write $c=(12\cdots n)$, with $n\ge 2$. Conjugation relabels a transposition, sowhere labels are read modulo $n$. In particular the subgroup contains $(12),(23),\dots ,(n-1n)$. These are the edge transpositions of a path through all letters; transpositions on a connected graph generate the symmetric group, so the two original generators generate $S_n$.

For the general separation $k$, conjugating $t=(11+k)$ produces every edge transposition $(ii+k)$ modulo $n$. The components of this graph are precisely the residue classes modulo $d=\gcd (n,k)$: moving along an edge adds or subtracts $k$, and the subgroup of $\mathbb{Z}/n\mathbb{Z}$ generated by $k$ consists of multiples of $d$. Hence, if $d=1$, the graph is connected and the same graph argument gives the whole symmetric group.

For completeness, the graph argument can be proved without assuming a generating-set theorem. On a simple path $v_0,\dots ,v_{\ell }$, put $t_j=(v_{j-1}{v}_j)$. ThenThis is a conjugate of the last edge transposition; connectivity therefore supplies every transposition, and part (a) supplies every permutation.

If $d>1$, there are $d$ residue blocks of size $n/d>1$, since $1\le k<n$. The cycle $c$ permutes these blocks, and $t$ swaps two letters in the same block. Both preserve this block system, so their generated subgroup does too. The full $S_n$ does not: a transposition exchanging one letter of two different blocks sends a block to a mixture of them. Thus the subgroup is proper. This provesThus a cycle and a transposition generate the symmetric group exactly at coprime separation. The obstruction is preservation of a partition, not failure of transitivity: the $n$-cycle already acts transitively even when $d>1$.