A cycle and a transposition generate the symmetric group exactly at coprime separation

For $n\ge 2$ and $1\le k<n$, an $n$-cycle $c=(12\dots n)$ and $t=(11+k)$ generate $S_n$ exactly when $\gcd (n,k)=1$. Their conjugate transpositions connect labels differing by $k$ modulo $n$. This graph is connected exactly at coprime separation, so transpositions on a connected graph generate the symmetric group. Otherwise residue classes modulo $\gcd (n,k)$ form a nontrivial block system preserved by both generators.