Adaptor protein (source code)

= Adaptor protein

An <adaptor protein> connects other components of a molecular pathway through binding interactions. Multiple interaction domains can bring a <receptor>, an <enzyme> and a cytoskeletal partner into one local assembly. The adaptor need not itself catalyse the pathway’s <chemical reaction>. Its abundance and localization can still regulate signalling by changing which partners encounter one another. <Nck> illustrates an adaptor linking phosphorylation-dependent recognition to downstream assemblies. <Phase transitions in the assembly of multivalent signalling proteins by Pilong Li and others>[2012, nephrin-Nck-N-WASP assembly]{ref}