An adaptor protein connects other components of a molecular pathway through binding interactions. Multiple interaction domains can bring a receptor, an enzyme and a cytoskeletal partner into one local assembly. The adaptor need not itself catalyse the pathway’s chemical reaction. Its abundance and localization can still regulate signalling by changing which partners encounter one another. Nck illustrates an adaptor linking phosphorylation-dependent recognition to downstream assemblies. [ref]
A signalling adaptor with several recognition domains, useful in reconstituted studies of multivalency and assembly.
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