= Andrei Kuzmichev
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<Andrei Kuzmichev> led a 2002 study identifying <histone methyltransferase> activity in a human <protein complex> containing Enhancer of Zeste. Biochemical isolation linked the complex to methylation of <histone H3>, with activity depending on an intact <SET domain>.<Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein by Andrei Kuzmichev and others>[Abstract: isolated complex, histone substrates and SET-domain requirement]{ref}
The contribution connected a regulator of <gene expression> to a specific chemical activity on <chromatin>. Measuring a <histone methylation> reaction and disrupting a required domain supplied more mechanistic information than observing that two <proteins> occur in the same <cell>.
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