Andrei Kuzmichev led a 2002 study identifying histone methyltransferase activity in a human protein complex containing Enhancer of Zeste. Biochemical isolation linked the complex to methylation of histone H3, with activity depending on an intact SET domain.[ref]
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein by Andrei Kuzmichev and others. Abstract: isolated complex, histone substrates and SET-domain requirement
The contribution connected a regulator of gene expression to a specific chemical activity on chromatin. Measuring a histone methylation reaction and disrupting a required domain supplied more mechanistic information than observing that two proteins occur in the same cell.
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