BLOSUM (source code)
= BLOSUM
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A <BLOSUM> matrix assigns amino-acid substitution scores estimated from conserved aligned blocks of <proteins>. Related sequences are clustered to reduce overrepresentation, and observed replacement frequencies are compared with background frequencies. Positive scores favour a pairing relative to that background; negative scores disfavor it. The matrix number identifies the clustering identity threshold, not the percentage identity of every sequence pair to which the matrix can be applied. <Amino acid substitution matrices from protein blocks by Steven Henikoff and Jorja G. Henikoff>[1992, block construction, clustering and log-odds scores]{ref}
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