= Contributory-causal treatment development
A research approach that identifies a potentially modifiable maintaining process, changes it experimentally and tests consequences for a clinical difficulty. Changing one contributory cause need not eliminate the difficulty, and a multicomponent manipulation does not identify one exclusive pathway.<Effects of cognitive behaviour therapy for worry on persecutory delusions in patients with psychosis (WIT): a parallel, single-blind, randomised controlled trial with a mediation analysis by Daniel Freeman and others>[Lancet Psychiatry 2, 305–313; 150 patients, six worry sessions plus usual care versus usual care, eight-/24-week outcomes]{ref}
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