A research approach that identifies a potentially modifiable maintaining process, changes it experimentally and tests consequences for a clinical difficulty. Changing one contributory cause need not eliminate the difficulty, and a multicomponent manipulation does not identify one exclusive pathway.[ref]
Effects of cognitive behaviour therapy for worry on persecutory delusions in patients with psychosis (WIT): a parallel, single-blind, randomised controlled trial with a mediation analysis by Daniel Freeman and others. Lancet Psychiatry 2, 305–313; 150 patients, six worry sessions plus usual care versus usual care, eight-/24-week outcomes
A trial of digital CBT for insomnia versus usual practice in university students with insomnia. Changes in psychotic experiences support investigation of sleep as a contributory process, but the population and comparator constrain application to clinical delusions.[ref]
The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis by Daniel Freeman and others. Lancet Psychiatry 4, 749–758; 3755 university students with insomnia, digital CBT versus usual practice and population limits
A randomised trial of a brief worry-focused intervention added to standard care for persistent persecutory delusions. The standard-care comparator permits inference about the added package, while unequal therapeutic contact limits a more ingredient-specific claim.[ref]
Effects of cognitive behaviour therapy for worry on persecutory delusions in patients with psychosis (WIT): a parallel, single-blind, randomised controlled trial with a mediation analysis by Daniel Freeman and others. Lancet Psychiatry 2, 305–313; 150 patients, six worry sessions plus usual care versus usual care, eight-/24-week outcomes
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