= D. I. Beller
{c}
<D. I. Beller> is the first author of a 1982 study relating <Mac-1> to a specific function of the <complement system>. The investigators used an <antibody> against <Mac-1> and a <rosette assay>, in which appropriately coated <red blood cells> bind around immune cells. The antibody inhibited binding mediated by the complement fragment <iC3b>, while selected other receptor-dependent binding remained intact.<Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor by D. I. Beller and others>[Abstract: antibody inhibition of complement-fragment-dependent rosetting; Journal of Experimental Medicine 156, 1000–1009, 1982]{ref}
The controls separated selective inhibition from indiscriminate loss of cell binding. The original conclusion was that <Mac-1> was identical to, or closely associated with, the relevant complement-receptor function. A blocking experiment can establish a strong functional association without, by itself, resolving every molecular detail of that association.<Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor by D. I. Beller and others>[Abstract: control antibodies, receptor specificity and bounded identity conclusion]{ref}
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