D. I. Beller is the first author of a 1982 study relating Mac-1 to a specific function of the complement system. The investigators used an antibody against Mac-1 and a rosette assay, in which appropriately coated red blood cells bind around immune cells. The antibody inhibited binding mediated by the complement fragment iC3b, while selected other receptor-dependent binding remained intact.[ref]
Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor by D. I. Beller and others. Abstract: antibody inhibition of complement-fragment-dependent rosetting; Journal of Experimental Medicine 156, 1000–1009, 1982
The controls separated selective inhibition from indiscriminate loss of cell binding. The original conclusion was that Mac-1 was identical to, or closely associated with, the relevant complement-receptor function. A blocking experiment can establish a strong functional association without, by itself, resolving every molecular detail of that association.[ref]
Anti-Mac-1 selectively inhibits the mouse and human type three complement receptor by D. I. Beller and others. Abstract: control antibodies, receptor specificity and bounded identity conclusion
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