A spacetime is a smooth four-dimensional manifold equipped with a smooth Lorentzian metric, conventionally of metric signature , and a choice of time orientation. The usual manifold assumptions include the Hausdorff space and second-countable space conditions. A physical model also specifies matter fields and requires the Einstein field equations and matter equations.
Diffeomorphism invariance of general relativity means that relabelling events by a smooth invertible map, while transforming the metric tensor and every matter field together, preserves the form of the equations. Passively, a coordinate change gives new components for the same geometric fields. Actively, pulling all fields back by a diffeomorphism gives another representative of the same physical geometry, subject to any prescribed boundary conditions or boundary symmetries.
The geometry and matter together carry the physical content; coordinate labels do not. A diffeomorphism need not be an isometry of a fixed metric, and unrelated metrics are not automatically physically equivalent.