= Experimental tractability
<Experimental tractability> is the practical ability to cultivate a system, manipulate the variables of interest, and obtain an interpretable readout with appropriate <scientific controls>. In <Saccharomyces cerevisiae>, inexpensive cultivation, accessible <haploid> and <diploid> states, and tools for introducing <DNA> make controlled changes of <genotype> feasible. A <haploid> <biological strain> exposes a changed <allele> without a second copy at that <genetic locus>, while crosses and <meiosis> permit tests of inheritance. <Budding Yeast for Budding Geneticists: A Primer on the Saccharomyces cerevisiae Model System by Andrea A. Duina and others>[Duina, Miller and Keeney (2014), introduction, Figure 2 and Experimental Toolkit and Related Resources]{ref}
An accessible readout is not necessarily a direct measurement of the mechanism. Growth of a <biological colony> integrates many cellular functions. Failure to grow could reflect the intended <gene deletion>, unsuitable conditions, failed <genetic transformation>, or another <mutation>. Matching the <genetic background> and using <scientific controls> narrows these alternatives. Ease of doing an experiment and strength of its inference are distinct advantages.
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