Experimental tractability is the practical ability to cultivate a system, manipulate the variables of interest, and obtain an interpretable readout with appropriate scientific controls. In Saccharomyces cerevisiae, inexpensive cultivation, accessible haploid and diploid states, and tools for introducing DNA make controlled changes of genotype feasible. A haploid biological strain exposes a changed allele without a second copy at that genetic locus, while crosses and meiosis permit tests of inheritance. [ref]
Budding Yeast for Budding Geneticists: A Primer on the Saccharomyces cerevisiae Model System by Andrea A. Duina and others. Duina, Miller and Keeney (2014), introduction, Figure 2 and Experimental Toolkit and Related Resources
An accessible readout is not necessarily a direct measurement of the mechanism. Growth of a biological colony integrates many cellular functions. Failure to grow could reflect the intended gene deletion, unsuitable conditions, failed genetic transformation, or another mutation. Matching the genetic background and using scientific controls narrows these alternatives. Ease of doing an experiment and strength of its inference are distinct advantages.
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