If , then , the cell-rich material fills the gap, and
If , then the core disappears and
For the physical ordering , increasing the cell-free layer thickness monotonically lowers between these limits, exactly as intuition and the Fahraeus--Lindqvist effect suggest.
The Fahraeus--Lindqvist effect is the decrease of blood's apparent or effective viscosity as a microvessel narrows through much of the physiological small-vessel range. Deformable red blood cells migrate away from the wall and concentrate near the centre, creating a cell-free layer of relatively low-viscosity plasma beside the vessel wall. Because the largest shear occurs near the wall, replacing cell-rich blood there by plasma reduces hydraulic resistance particularly effectively. At diameters comparable with a red blood cell, confinement eventually invalidates this decreasing trend.