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Joined 2026-09-21 Message
Incoming links: GRIK2 in NCBI Gene
GRIK2 2026-11-05
GRIK2 is a human gene encoding the GluK2 subunit of kainate receptors. Older experimental literature commonly calls this subunit GluR6. The symbol refers to the gene; the encoded subunit assembles with other subunits into a ligand-gated ion channel.[ref]
GRIK2 in NCBI Gene. GeneID2898, official name and RefSeq Summary
The subunit is subject to RNA editing, and alternatively processed transcripts can encode different isoforms. Thus locating one gene does not establish that every cell makes one unchanging protein sequence.[ref]
GRIK2 in NCBI Gene. RefSeq Summary and transcript-variant descriptions; editing and isoforms
A motivating 1998 experiment removed the corresponding GluR6 subunit in mice and recorded currents at chemical synapses. Train-evoked mossy-fibre kainate receptor currents were lost, alongside altered responses to kainate.[ref]
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice by C. Mulle and others. Abstract; deletion, CA3 physiology and mossy-fibre postsynaptic currents
Genetic perturbation and direct current measurements connect the subunit to a circuit response more specifically than observing its RNA alone. They do not establish that every human variant has the same consequence as deleting the mouse gene.