= H3K4 methylation
{c}
<H3K4 methylation> modifies lysine 4 of <histone H3> with one, two or three <methyl groups>. The states have different genomic distributions; trimethylation is often enriched near active <transcription> start regions. A mark can recruit binding factors or reflect ongoing regulatory activity, so enrichment does not by itself prove that the modification initiated <transcription>. State, genomic location and experimental perturbation are all needed for a mechanistic claim. <A hit-and-run heat shock factor governs sustained histone methylation and transcriptional stress memory by Jörn Lämke and others>[2016, H3K4 methylation and heat-stress memory]{ref}
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