H3K4 methylation modifies lysine 4 of histone H3 with one, two or three methyl groups. The states have different genomic distributions; trimethylation is often enriched near active transcription start regions. A mark can recruit binding factors or reflect ongoing regulatory activity, so enrichment does not by itself prove that the modification initiated transcription. State, genomic location and experimental perturbation are all needed for a mechanistic claim. [ref]
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