xPore 2026-10-20
A method for detecting differential RNA-modification signals using Gaussian mixture distributions of nanopore current, with condition-specific component proportions. A shifted signal requires biological interpretation as well as statistical separation.[ref]
Identification of differential RNA modifications from nanopore direct RNA sequencing with xPore by Ploy N. Pratanwanich and others. Method overview: shared current distributions and sample-specific modification fractions