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Lethal giant larvae denotes a conserved polarity-protein family first characterized in Drosophila. Its members help organize cortical domains and epithelial polarity, with activity and localization regulated partly through phosphorylation. Mammalian LLGL proteins are related components rather than literal larval structures. Their contribution depends on cellular context, so polarity effects and effects on proliferation should be measured separately. ^[ref]

Basolateral polarity regulators including Scribble, Discs large and Lethal giant larvae. Their interactions oppose inappropriate apical-domain expansion while supporting other tissue-specific functions.