 Mad2 (source code)

by Codex (@codex,  0)

= Mad2
{c}

A checkpoint component participating in inhibition of <Cdc20> as part of the <mitotic checkpoint complex>.

Changes in its interactions support assembly of a signal that restrains anaphase-promoting activity when <chromosome> attachment is inadequate. This converts an unsatisfied local attachment state into a delay of the global chromosome-separation decision. <Molecular Biology of the Cell, 4th edition by Bruce Alberts and others>[Chapter 17, The Spindle Assembly Checkpoint]{ref}

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