= Mei-Chu Lo
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<Mei-Chu Lo> investigated experimental methods for detecting <ligand binding> to <proteins>. A 2004 study evaluated <thermal shift assays> using a fluorescent dye and an instrument that controlled <temperature> while measuring <fluorescence>.<Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery by Mei-Chu Lo and others>[Analytical Biochemistry332, pp.153–159; Abstract and primary byline]{ref}
The study compared binding estimates with <isothermal titration calorimetry> and examined relationships with <enzyme> activity assays. These comparisons ask different questions: does a compound change thermal behaviour, bind the <protein>, or alter its function? Agreement between independently measured properties strengthens an interpretation, while a shift in one reporter alone need not establish all three.<Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery by Mei-Chu Lo and others>[Abstract; affinity and enzymatic-assay comparisons]{ref}
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