In the birth-death master equation, The upward jump has rate and the downward jump rate , so the first two jump moments per unit time are and . The second-order Kramers-Moyal expansion gives the diffusion approximation of a birth-death process
For the associated Fokker-Planck equation, integrating by parts with vanishing moment boundary terms gives . Taking yields
For example, if , then , while the variance satisfies . The two boxed moment equations also follow exactly from the discrete Markov jump-process generator, since quadratic functions have no higher jump terms. A reflecting diffusion confined to can have extra boundary contributions; the formal approximation near extinction is not an exact replacement for the discrete process.