Nanopore sequencing
= Nanopore sequencing
<Nanopore sequencing> infers a nucleic-acid sequence from changes in electrical current as a strand passes through a nanometre-scale pore. The signal depends on several nearby bases rather than one perfectly isolated base at a time. It supports long reads and direct <RNA> measurement, but base calling and modification inference require calibrated models. Comparison of conditions can detect altered signal patterns without identifying every chemical modification uniquely. <Identification of differential RNA modifications from nanopore direct RNA sequencing with xPore by Ploy N. Pratanwanich and others>[2021, current distributions, differential modification inference and direct RNA data]{ref}