= Notch signalling
{c}
<Notch signalling> is a contact-dependent signalling pathway in which a <ligand> on one <cell> activates a <receptor> on another. Proteolytic processing releases an intracellular <receptor> fragment that can enter the <cell nucleus> and participate in <transcription> control. <receptor> processing therefore links a local contact to a nuclear response. During vertebrate <somitogenesis>, coupling through <Notch signalling> can coordinate neighbouring oscillators without being identical to their intracellular oscillation mechanism. https://www.nature.com/articles/30756[Schroeter, Kisslinger and Kopan, 1998, ligand-induced proteolytic release and transcriptional signalling]{ref}
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