Because the measurement can cross the threshold in both directions while the model declares dementia irreversible, one needs the diagnostic rule's sensitivity
and specificity
These quantify false negative and false positive state classifications and permit a hidden-state or misclassification model instead of treating every threshold crossing as the true irreversible onset.
If is future time to dementia from age 50, its survival function is
The tail-sum formula for expectation gives the expected future time alive without dementia:

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