Let
be the reaction Jacobian at the homogeneous equilibrium. Stability without diffusion gives
For a spatial Fourier mode with eigenvalue , the linearized matrix is
Its trace is even more negative than , so instability occurs exactly when its determinant becomes negative. Put and . Then
This upward-opening quadratic is negative for some exactly when its minimum occurs at positive and lies below zero:
The second strict inequality implies the first when written with a positive square root, so the two-species diffusion-driven instability criterion becomes

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