PITX2 (source code)
= PITX2
{c}
<PITX2> is a <homeobox> <transcription factor> involved in developmental patterning, including left-right asymmetry. It connects asymmetric upstream signalling to tissue-specific <gene regulation> during organ development. In vertebrate heart and gut development, its expression helps interpret <positional information> rather than mechanically turning an organ by itself. Expression, target regulation and final organ shape are distinct levels of evidence. <The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping by M. Campione and others>[1999, asymmetric expression and organ-looping analysis]{ref}
Back to article page
