PITX2 is a homeobox transcription factor involved in developmental patterning, including left-right asymmetry. It connects asymmetric upstream signalling to tissue-specific gene regulation during organ development. In vertebrate heart and gut development, its expression helps interpret positional information rather than mechanically turning an organ by itself. Expression, target regulation and final organ shape are distinct levels of evidence. [ref]
The homeobox gene Pitx2: mediator of asymmetric left-right signaling in vertebrate heart and gut looping by M. Campione and others. 1999, asymmetric expression and organ-looping analysis
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