= Protein–DNA interaction
A <protein–DNA interaction> is physical association between a <protein> and <DNA>. Contacts can depend on base sequence, <DNA> shape, charge or interactions with other bound factors. A <transcription factor> can recognize selected regulatory sites, while <histones> package much larger fractions of the <genome>. Detecting association establishes contact or proximity under the assay conditions; regulation, bending or bridging requires additional functional or structural evidence. <Molecular Biology of the Cell, 4th edition by Bruce Alberts and others>[Chapter 7, DNA-Binding Motifs in Gene Regulatory Proteins]{ref}
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