{c}

<S. Chu> investigated how <gene expression> coordinates <meiosis> and formation of reproductive <cells> in <budding yeast>. A 1998 study identified <Ndt80> as a <transcription factor> activating a set of <genes> needed for these processes.<Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80 by S. Chu and others>[Molecular Cell 1, pp. 685–696; Abstract and primary byline]{ref}

Producing <Ndt80> in vegetatively growing <cells> activated normally developmentally regulated <genes>; purified experimental <Ndt80> also bound a conserved upstream <DNA> sequence. These complementary experiments connected a regulatory <protein> to both <DNA> recognition and a change in <transcription>, rather than relying only on correlated timing of <gene expression>.<Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80 by S. Chu and others>[Abstract; ectopic synthesis and DNA-binding experiments]{ref}


 S. Chu (source code)