S. Chu investigated how gene expression coordinates meiosis and formation of reproductive cells in budding yeast. A 1998 study identified Ndt80 as a transcription factor activating a set of genes needed for these processes.[ref]
Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80 by S. Chu and others. Molecular Cell 1, pp. 685–696; Abstract and primary byline
Producing Ndt80 in vegetatively growing cells activated normally developmentally regulated genes; purified experimental Ndt80 also bound a conserved upstream DNA sequence. These complementary experiments connected a regulatory protein to both DNA recognition and a change in transcription, rather than relying only on correlated timing of gene expression.[ref]
Gametogenesis in yeast is regulated by a transcriptional cascade dependent on Ndt80 by S. Chu and others. Abstract; ectopic synthesis and DNA-binding experiments
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